Alveolar Epithelial Damage and Dysfunction as Common Features of Ischemia/Reperfusion Injury and Primary Graft Dysfunction in Lung Transplants

Primary Graft Dysfunction After Lung Transplantation.

Primary graft dysfunction is a form of acute injury after lung transplantation that is associated with significant short- and long-term morbidity and mortality. Multiple mechanisms contribute to the pathogenesis of primary graft dysfunction, including ischemia reperfusion injury, epithelial cell death, endothelial cell dysfunction, innate immune activation, oxidative stress, and release of infl...

UPDATE IN INTENSIVE CARE: TRANSPLANTS Primary graft dysfunction after lung transplantation

Lung transplantation is a therapeutic option for pulmonary diseases in which the other treatment options have failed or in cases of rapid disease progression. However, trans-plantation is not free from complications, and primary graft dysfunction is one of them. Primary graft dysfunction is a form of acute lung injury. It characteristically develops during the immediate postoperative period, be...

Lung Injury Alveolar Epithelial Dysfunction in Acute TNF-Induced Death Signaling Triggers

Long Term Impact of Primary Graft Dysfunction after Lung Transplantation

According to the International Society for Heart and Lung Transplantation (ISHLT) Registry, graft failure accounted for 24.7% of deaths within 30 days of transplantation among adult lung recipients between 1992 and 2012 [1]. Although important details distinguishing different causes of early graft failure may be missing from the Registry data, it is likely that primary graft dysfunction (PGD) i...

Risk factors for chronic graft dysfunction in 918 renal transplants.

CHRONIC rejection or chronic allograft dysfunction (CD) persists as one of the most prevalent causes of long-term kidney graft loss. As a consequence, the longterm survival and half-life of grafts remains poor, despite optimistic results from a recent publication. Chronic allograft dysfunction is a process of gradual destruction of the kidney graft, dominated by progressive vascular obliteratio...